In the context of the rapidly advancing global biopharmaceutical and precision medicine fields, the integrity and safe transit of biological samples are critical determinants of experimental and diagnostic success. AIC Biological Bags is establishing itself as a trusted partner for medical and research institutions through its in-depth R&D and strict quality control in the field of specialized transport packaging.

Our products are not ordinary packaging; they are exclusively designed for the shipment of high-value biological samples, diagnostic reagents, and cold chain items. They strictly adhere to international and industry regulations, ensuring the safety of samples at every step, from collection point to laboratory.

 

Specialization: Ensuring Sample Integrity and Compliance

 

The core advantage of AIC's biological sample transport packaging lies in its deep adherence to medical regulations and high-standard safety design:

 

Regulatory Compliance (UN 3373): Our packaging strictly complies with the requirements of the International Air Transport Association (IATA) and relevant national health regulatory bodies for the transport of Infectious Substances (e.g., UN 3373, Biological Substance, Category B), ensuring smooth and lawful global shipping.

 

Superior Leak Protection: Utilizing multi-layer construction and specialized sealing technology, our packaging offers exceptional leak-proof protection. This is crucial for preventing the potential spread of biohazards and safeguarding personnel and public safety.

 

Temperature Resistance and Durability: The packaging materials possess excellent temperature resistance, making them compatible with the low-temperature environments of cold chain logistics, and ensuring the packaging maintains structural stability against damage throughout complex logistics processes.

 

Driven by Innovation: Facing the Future of Biopharmaceutical Logistics

 

AIC continuously invests in innovation to address the challenges in biopharmaceutical logistics:

 

Customized Solutions: We offer packaging with customizable sizes, insulating layers, and indicators to meet the transport needs of various sample types (such as blood, urine, tissue, or cells) and different temperature control requirements (such as frozen, refrigerated, or ambient).

 

Traceability Support: The packaging design facilitates easy labeling and scanning to support logistics information traceability, which is an indispensable part of clinical trials and diagnostic procedures.

 

AIC: Your Reliable Pharmaceutical Logistics Partner

 

AIC Biological Sample Shipping Packaging is your professional tool for ensuring the safety of high-value biological assets. Choosing us means choosing safety, compliance, and reliability, allowing your research and medical teams to focus on core tasks without worrying about the risks of sample transport.

The revolutionary Low Speed Centrifugation Concept (LSCC) has proven that the key to superior tissue regeneration lies in the selective enrichment of leukocytes and platelets. As research confirms, lower RCF protocols significantly boost the release of essential growth factors like VEGF and TGF-β1.

However, the scientific community has long been hindered by the limitations of traditional flow cytometry. Standard methods often require complex anti-coagulation pre-treatment, which can mask the true, immediate activation state of the cells.

Introducing Poclight's Pioneering CD Factor Detection System—a proprietary methodology designed to move beyond "static counting" and into the era of "functional insight."

 

Three Core Breakthroughs for Clinical Excellence

 

1. Resilience Against Platelet Interference In many clinical scenarios, especially with patients suffering from low platelet counts, traditional detection is prone to error due to platelet aggregation and concentration fluctuations. Poclight's unique methodology is independent of platelet aggregation and concentration, finally solving the long-standing challenge of functional assessment in low-count patients. We provide a clear, accurate diagnostic window where others see only noise.

2. Standardized, High-Speed Performance Time is critical in clinical settings. Unlike the multi-step, complex pre-processing required for flow cytometry, our standardized system requires no complex pre-treatment.

Speed: Obtain reliable results in just 5–10 minutes.

Dual Functionality: Simultaneously detect platelet activation states and aggregation functions, providing a comprehensive metabolic profile of the regenerative matrix in real-time.

3. A One-Stop Solution for Life Sciences and Clinics We provide a seamless bridge between laboratory research and clinical application. By offering a one-stop solution for CD factor analysis, we are pushing the boundaries of platelet function research into a more precise, efficient, and data-driven new stage.

True Accuracy Reflects True Activation

Poclight's technology captures the authentic and immediate state of cellular activation. By reflecting the cells as they truly behave within the patient’s own biological environment, we provide clinicians with the most accurate basis for judgment.

Contact us today to discover how our exclusive CD Factor Detection Kits can redefine your outcomes.

 

 

 

 

The combination of artificial intelligence (AI) and optical coherence tomography (OCT) is revolutionizing the diagnostic model of ophthalmic diseases. The core of this integration lies in combining the powerful data analysis capabilities of AI with the high-resolution biological tissue structure imaging of OCT, thereby providing doctors with insights that exceed the limits of human vision. Specifically, AI has provided revolutionary assistance in the following aspects

I. Core Support: Faster, More Accurate, and Smarter
1.Ultra-high-speed quantitative analysis and screening
What to do: AI algorithms can automatically complete the analysis of the entire OCT three-dimensional volume scan within seconds, accurately segment each layer of the retina structure (such as the nerve fiber layer, photoreceptor cell layer, etc.), and measure its thickness and volume.
Traditional pain points: Manual measurement by doctors is time-consuming and labor-intensive, and it is difficult to quantify the entire retina so precisely.
The changes brought about: It provides objective and repeatable quantitative data for glaucoma (focusing on the optic disc and nerve fiber layer) and macular diseases (focusing on the thickness changes of each layer), greatly shortening the initial assessment time.

2. Anomaly detection and lesion identification
What to do: The AI model, trained on a vast amount of labeled data, can automatically identify and label various lesions in OCT images like an experienced expert, such as
Diabetic macular edema: Detection of fluid accumulation within the retina (cystoid edema).
Age-related macular degeneration: Identification of vitreous warts, subretinal fluid, choroidal neovascularization, etc.
Retinal vein occlusion: Macular edema and hemorrhage are found.
Macular holes, epiretinal membranes, etc.
The changes brought about: AI can act as the "first reader", quickly marking suspicious lesion areas, preventing the missed diagnosis of tiny lesions due to visual fatigue or lack of experience, and is particularly suitable for large-scale community screening.

3. Disease classification and severity grading
What to do: AI can not only detect lesions but also automatically classify and stage diseases. For instance, to determine whether AMD is dry or wet, to grade the risk of visual field defects in glaucoma, or to assess the severity of diabetic retinopathy.
The changes brought about: It provides doctors with standardized diagnostic references to assist in making treatment decisions and priorities (for example, which patients with wet AMD need urgent anti-VEGF treatment).

4. Predict disease progression and treatment response
What to do: This is the most cutting-edge application of AI. By analyzing the longitudinal OCT sequence images, the AI model can learn the patterns of disease development and predict the risk of future disease deterioration. At the same time, it can also predict the possible response of patients to specific treatments, such as anti-VEGF injections.
The changes brought about: achieving a leap from "diagnosing the present" to "predicting the future", making personalized medicine and preventive intervention possible.

Ii. Specific Manifestations in the Clinical Workflow
In screening scenarios: AI-OCT systems can be deployed in communities or physical examination centers. OCT scans are operated by technicians, and AI generates reports in real time, quickly screening out high-risk patients for referral to specialists, greatly improving the efficiency and coverage of screening.
1.In the outpatient setting:
Before the examination: The patient has completed the OCT scan.
2. During the examination: AI real-time analysis generates a preliminary report with color annotations, quantitative data, and suspicious findings before the doctor's consultation.
3. Doctor's Diagnosis: Doctors do not need to analyze from scratch from a vast amount of raw data. Instead, they directly review the AI's findings and, based on their own clinical experience, confirm, correct and make a final diagnosis. This is equivalent to having an "indefatigable assistant" complete all the basic measurements and initial screening work.
4. Follow-up Comparison: AI can automatically and precisely match and compare this scan with the patient's historical scans, highlighting the areas that have changed (improved or deteriorated), making the follow-up assessment clear at a glance.

Iii. Core Values for Ophthalmologists
1. Liberate productivity: Free doctors from heavy repetitive labor (measurement, comparison), allowing them to focus on decision-making, doctor-patient communication, and treatment plan formulation that require high-level clinical thinking.

2. Enhance diagnostic capabilities: As the "second pair of eyes", it provides objective and quantitative decision support, reduces diagnostic differences among individuals, and improves the consistency and accuracy of overall diagnosis.

3. Dealing with the data deluge: Modern OCT scans generate an enormous amount of data, and AI is an indispensable tool for processing and analyzing these big data.

4. Empowering grassroots and non-experts: Assist grassroots hospitals or general practitioners in initially identifying complex eye diseases, promote hierarchical medical treatment, and enable more patients to receive correct referral advice in a timely manner.

Also welcome to contact us, we are ZD Medical Inc.
Tel : +86-187 9586 9515
Email : sales@zd-med.com
Whatsapp/Mobile : +86-187 9586 9515

I. Evaluation of Core Technology Performance
1. Imaging quality and clarity

Resolution and contrast: Whether the vein images generated by the device are clear and can clearly distinguish the veins from the surrounding tissues (such as fat and skin pigments).

Penetration depth and adaptability: Whether the venous imaging effect is stable and reliable for patients of different body types (obese, thin), skin colors, ages (newborns to the elderly), and those with edema.

Anti-interference ability: Whether the imaging effect is affected under conditions such as strong ambient light, moist skin, tattoos or scars.

Real-time performance: Whether the imaging has no delay and can follow the movement of the probe or the pulsation of the blood vessel in real time.

2. Technical Principles and Safety

Imaging technology: Understand whether near-infrared light, ultrasound, or a combination of multispectral and other technologies are used. Different techniques have their own advantages and disadvantages (for example, infrared is good for superficial veins, while ultrasound is effective for deep veins).

---

Ii. Clinical Effectiveness Evaluation

This is the most crucial part and requires objective evidence to support it.
1.Review clinical literature and evidence-based evidence
Search for clinical research papers on this device (or similar technology) published in peer-reviewed journals.
Focus on key indicators
The success rate of the first puncture: After using the equipment, especially for difficult veins (such as pediatric, elderly, chemotherapy, and obese patients), the data on the improvement of the success rate of the first puncture.
Decreased number of puncture attempts: Whether the average number of punctures has significantly declined.
Shortened operation time: The total time required from locating the blood vessel to successful catheterization.
Has the incidence of patient complications decreased: Has the incidence of hematoma, permeation, phlebitis and needlestick injuries decreased?

Patient satisfaction: Whether the patient's self-reports of pain and anxiety have improved.

2. Obtain real-world feedback

Contact the purchased hospital: Inquire about the actual usage experience from the nursing staff and intravenous therapy specialist nurses in hospitals of the same level or higher (especially in key departments such as pediatrics, oncology, ICU, and emergency) that have already used this equipment.
On-site demonstration and trial use: It is required that the supplier conduct a demonstration in a real clinical environment of the hospital and have senior nurses from different departments of the hospital carry out blind tests (first conduct traditional touch/visual judgment without knowing the imaging results of the equipment, and then compare the images of the equipment) to evaluate whether the information provided by the equipment is indeed superior to the traditional method.
Observe the integration of the workflow: Whether the equipment can be easily integrated into the existing venipuncture process, and whether it will speed up the process or cause disruptions.

Iii. Evaluation of Operability and Practicality
1.Ergonomic design
Device form: Is it handheld, head-mounted or stand type? Whether it is lightweight, flexible and suitable for long-term operation.
Display method: Is the image directly projected onto the skin or displayed on an independent screen? Whether the projection/display is clear and intuitive, without the need for the operator to frequently adjust the viewing Angle.

Disinfection and protection: Whether the probe or the parts in contact with the patient are easy to disinfect or equipped with disposable protective covers, and meet the requirements of infection control.

2. Usability and learning curve

Is the interface intuitive and is the parameter adjustment simple?
How long does it take for medical staff to be trained before they can be used independently and effectively? Does the supplier provide complete training and support?

Iv. Economic and Operational Efficiency Assessment
1.Cost-benefit analysis
Direct costs: Equipment purchase price, consumables (if any), maintenance fees.
Indirect benefits/cost savings:
Reduce the waste of consumables (needles, dressings) caused by repeated punctures.
Reduce the additional processing costs caused by puncture failure or complications.
Enhance the efficiency of medical staff and save time for other nursing tasks.

The potential risk of medical disputes has been reduced.

2. Estimation of return on investment

Based on the proportion of patients with difficult venipuncture in our hospital and the annual puncture volume, estimate the comprehensive benefits that can be brought by improving the success rate and reducing the operation time, and calculate the approximate payback period of investment.

Also welcome to contact us, we are ZD Medical Inc.
Tel : +86-187 9586 9515
Email : sales@zd-med.com
Whatsapp/Mobile : +86-187 9586 9515

1. Lifespan: The designed lifespan of most professional-grade vein finder is typically around five years. Battery life: The performance of internal lithium batteries typically begins to decline after 300 to 500 complete charge and discharge cycles. It is recommended to keep the battery charged to avoid long-term complete depletion. Light source lifespan: Near-infrared (NIR) lasers or LED emitters typically have a rated lifespan of tens of thousands of hours and rarely suffer damage under normal clinical use.

2. Calibration Requirements Calibration is the key to ensuring that the "projected image" precisely coincides with the "actual vascular position". Self-calibration function: Many high-end models feature permanent alignment and self-calibration technology, eliminating the need for manual intervention during daily use. Regular verification: It is recommended to conduct a functional check every two months. The operator can project the projection onto the superficial blood vessels at a known position and observe whether the center of the projection is consistent with the tactile position (the error is usually less than 0.25mm). Return to factory calibration: If the equipment has been subjected to severe impact or dropped, resulting in double images, blurriness or positional deviation of the projected image, it is necessary to contact the manufacturer for professional optical calibration.

3. Durability and Daily Maintenance (Maintenance & Durability) Although the vascular detector is designed with drop protection, its internal optical components and precision sensors are relatively sensitive to the environment.

Suggestion

To maximize the return on investment for the equipment, it is recommended to establish an equipment file, recording the monthly cleaning date, battery health status and any drop accidents. This not only extends the lifespan of the equipment but also provides evidence of its good operation in the event of medical disputes.

Also welcome to contact us, we are ZD Medical Inc.
Tel : +86-187 9586 9515
Email : sales@zd-med.com
Whatsapp/Mobile : +86-187 9586 9515

1) Core Value: Provide a unique “surface vascular map”

Ophthalmic imaging equipment (such as OCT) focuses on the microscopic vascular structure of the fundus (retina, choroid), while venous detectors are adept at non-invasively visualizing the vascular network on the ocular surface and around the eye, especially:

The blood vessels of the sclera and conjunctiva

The blood vessels of the skin around the eyes and the eyelid margin

This provides ophthalmologists with a brand-new dimension of observation.



2) Integration and supplementation of specific work processes

1. Diagnosis and Screening stage: Viewing “Systemic Diseases” from “Ocular Surface Blood Vessels”

Many systemic diseases can affect both the fundus blood vessels and the ocular surface blood vessels simultaneously. Venous detection devices can serve as a rapid and non-invasive initial screening tool.

Supplement the workflow of OCT

Scene: A diabetic patient comes for an annual eye examination.

The current process: The doctor uses OCT to examine the retinal microvessels, looking for signs of diabetic retinopathy such as microaneurysms and non-perfusion areas.

Supplementary value: At the initial stage of the consultation, a venous detector is first used to observe the blood vessels of the patient’s bulbar conjunctiva. Research has found that systemic diseases such as diabetes can cause morphological changes such as distortion and dilation of conjunctival blood vessels. If any abnormalities are detected, it can provide stronger directivity for OCT examination and alert doctors that the patient may have uncontrolled systemic risks.

Advantages: The examination process is faster and more comfortable, with high patient tolerance, and it is easy to conduct dynamic observation.



2. Surgical planning and navigation: Enhance the precision and safety of the surgery

This is one of the most promising application scenarios of venous detectors in ophthalmology.

Supplement the workflow of cataract surgery

For cataract patients with limbal stem cell insufficiency, thin sclera or those requiring complex incisions, it is crucial to understand the vascular distribution in the limbal area of the corneosclera and the surgical incision area before the operation. This can prevent intraoperative bleeding and affect the surgical field of view.

Supplementary value: Before the operation, a venous detector is used to draw the vascular network of the corneoscleral margin, which helps doctors precisely plan the position of the surgical incision, avoid the main blood vessels, achieve “blood-free” surgery, and improve the efficiency and safety of the operation.

Supplement the workflow of glaucoma surgery

Question: When performing glaucoma drainage device implantation (such as Ah valve implantation), it is necessary to suture and fix it in the water tank area (usually located behind the equator of the eyeball). This area is rich in blood vessels, and intraoperative bleeding is a common complication.

Supplementary value: Before the operation, a venous detector is used to precisely locate the surface blood vessels in the water tank area. With the assistance of the surgical navigation system, doctors can select areas with relatively sparse blood vessels for suturing, significantly reducing the risk of bleeding and postoperative complications.

Supplement the workflow of eye plastic surgery/orbital surgery

Blepharoplasty, orbital tumor resection, etc., require an accurate understanding of the vascular anatomy of the eyelid and orbit.

Supplementary value: The venous detector can clearly outline the direction of the arteries and veins around the eyes, serving as a “real-time vascular map” for surgical navigation. It helps doctors perform precise operations, avoid damaging important blood vessels, and reduce intraoperative bleeding and postoperative hematoma.



3. Treatment and efficacy evaluation stage: Achieve visual efficacy monitoring

Supplement the dry eye treatment workflow

Meibomian gland dysfunction is the main cause of dry eye. Intense pulsed light (IPL) is an effective treatment method, and one of its mechanisms of action is to close the abnormal blood vessels in the eyelid.

Supplementary value

Before treatment: Use a venous detector to assess the vascular density and morphology of the eyelid margin to provide baseline data for treatment.

After treatment: Re-imaging is conducted to visually display the closure of abnormal blood vessels after IPL treatment, providing objective imaging evidence for efficacy evaluation. This is unique information that existing corneal topography or dry eye analyzers cannot provide.

Supplement the treatment workflow for ocular surface inflammatory diseases:

Allergic conjunctivitis, pterygium and other diseases are accompanied by obvious conjunctival vascular congestion.

Supplementary value: Quantitative analysis of congested blood vessels (such as vessel diameter and density) using a venous detector can objectively evaluate the effects before and after anti-inflammatory drug treatment, providing data support for clinical research and personalized treatment.

Also welcome to contact us, we are ZD Medical Inc.
Tel : +86-187 9586 9515
Email : sales@zd-med.com
Whatsapp/Mobile : +86-187 9586 9515

1.  Introduction

 

In the world of aesthetic medicine, the desire for lasting solutions has driven innovations beyond traditional fillers. While many dermal fillers provide immediate volume restoration, the trend is shifting towards treatments that stimulate natural collagen production. Enter the Hyamax® PLLA Injectable Poly-L-Lactic Acid Filler. Unlike typical volume boosters, it’s a collagen stimulator. Offering not just immediate improvement of skin texture, moisturizing and brightening of the skin,but biological revitalization,  which lead to a natural facial volume restoration for up to two years.  Let's explore the science behind this breakthrough.

 

The Science Behind PLLA: A Bio-Stimulatory Approach

PLLA (Poly-L-Lactic Acid) signifies a significant advancement from traditional volume replacement to bio-stimulation. Unlike traditional hyaluronic acid (HA) fillers, which plump the skin through physical filling and water attraction,, PLLA acts as a catalyst for collagen production. Upon injection, PLLA microparticles create a supportive framework beneath the skin. As the body gradually absorbs these particles, a natural inflammatory response is triggered, stimulating fibroblasts to produce new collagen. The outcome is long-lasting facial volume generated not by the filler itself, but by the body’s rejuvenated collagen.

 

The Mechanism of action (MOA) of PLLA

 

A Long-Lasting Solution: How Hyamax® PLLA Works

The claim of up to two years of results comes from the gradual bio-stimulation of collagen. Unlike temporary fillers, the collagen production process triggered by PLLA takes time, gradually building results over several months. This slow and natural regeneration leads to longer-lasting and more natural-looking improvements. The final result comes from your body’s own enhanced collagen matrix, not just the injected material.

 

 

The Dual Power of Hyamax® PLLA: Two Components for Maximum Effect

Hyamax® PLLA comes in a two-bottle system for optimal injection experience and results. Bottle A contains 150 mg of PLLA microspheres, the key collagen-stimulating agent.  Hyamax RUSH™ 3.0 PLLA Microsphere Technology provides optimal crystallization and molecular weight, ensuring a consistent degradation rate with effectiveness lasting up to 24 months. Bottle B contains 5 mL of non-crosslinked Hyaluronic Acid and lidocaine hydrochloride. This unique formula offers dual benefits: PLLA stimulates collagen production over time, while the HA provides immediate hydration, creating a smooth, plump appearance right after the procedure. The lidocaine ensures patient comfort during the injection process. Processed microspheres and a suitable vehicle allow for easy application; simply mix and shake before use. 

Who is Hyamax® PLLA For? 

Hyamax® PLLA is perfect for individuals with the following concerns: 

• Enlarged pores 
• Acne scars 
• Loss of skin volume 
• Dark circles and hollow under-eyes 
• Fine lines and wrinkles around the eyes and neck 
• Dry, dull skin that lacks radiance

 

WHAT IS CaHA FILLER?

 

CaHA stands for Calcium Hydroxylapatite, which is a substance used in cosmetic procedures, particularly in dermal fillers. It is a biocompatible material that has been approved by regulatory bodies in various countries for use in filling deep lines and wrinkles, as well as for adding volume to certain areas of the face. When injected into the skin, CaHA stimulates collagen production, which can help improve skin texture and firmness over time. It's a popular option for those seeking non-surgical facial rejuvenation.

 

 

 

WHY CHOOSE CaHA FILLER?

 

Choosing a CaHA filler can be advantageous for several reasons:

Stimulates collagen production: CaHA stimulates the body's natural collagen production, leading to gradual improvements in skin texture and firmness over time. This can result in more natural-looking and longer-lasting results compared to fillers that simply add volume.

 

 

Biocompatibility: CaHA is a biocompatible material, with metabolic products (Ca²⁺, PO₄³⁻) that are naturally present in the body. This demonstrates its high biocompatibility, meaning it is well-tolerated by the body and carries a low risk of allergic reactions or other adverse effects.

 

*In vivo metabolic pathways of CaHA

 

Gradual degradation: Over time, the CaHA particles in the filler are gradually broken down by the body and metabolized, leading to a natural-looking decline in the effects of the filler. Studies have shown CaHA could be degraded within human body 30 months post-injection, proving its excellent biodegradability.

 

 

Long-lasting results: Calcium hydroxylapatite fillers typically provide longer-lasting results compared to some other types of fillers. The effects can last up to a year or even longer in some cases.

 

WHAT'S THE DIFFERENCES OF CaHA FILLER AND TRADITIONAL HA FILLER?

 

The main differences between Calcium Hydroxylapatite (CaHA) fillers and traditional Hyaluronic Acid (HA) fillers lie in:

 

Longevity: CaHA fillers typically provide longer-lasting results compared to traditional HA fillers. The effects of CaHA fillers can last up to a year or more, whereas HA fillers usually last around 6 to 18 months, depending on the specific product and treatment area.

 

Mechanism of action: CaHA fillers work by providing immediate volume to the treated area while also stimulating the body's natural collagen production. This collagen stimulation helps improve skin texture and firmness over time. HA fillers primarily work by attracting and retaining water molecules, thereby adding volume to the treated area. They do not stimulate collagen production to the same extent as CaHA fillers.

 

Both types of fillers have their own advantages and are suitable for different individuals and treatment goals. The choice between CaHA and HA fillers depends on factors such as the specific concerns being addressed, desired duration of results, and individual preferences. It's essential to consult with a qualified healthcare provider to determine the most suitable filler for your needs.

 

WHAT IS HYAMAX® CaHA Lido?

HYAMAX® CaHA Lido is an innovative hybrid biostimulator and advanced injectable treatment that combines hyaluronic acid (HA) to enhance immediate volume increase with calcium hydroxyapatite (CaHA) for long-term collagen stimulation. This award-winning treatment visibly tightens and lifts the jawline and cheeks, delivering youthful and natural-looking results. The addition of Lidocaine in HYAMAX® CaHA Lido enhances the patient experience by reducing discomfort and pain during the procedure.