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When OCT meets artificial intelligence, a diagnostic revolution quietly arrives:

Automatic lesion identification: The algorithm based on convolutional neural network (CNN) can complete the pathological analysis of ophthalmic OCT images within 0.3 seconds, identifying dozens of lesions such as macular holes and retinal detachment, with an accuracy rate exceeding 95%

Real-time surgical navigation: During tumor surgery, the AI-enhanced OCT system can dynamically mark the tumor boundary. Experimental data show that this reduces the residual rate of malignant tissues by 40%

Elastography breakthrough: The Bayesian neural network strain reconstruction technology developed by the team from Guangdong University of Technology has successfully solved the problem of measuring signals related to chromatographic regression, enabling OCT to map the mechanical properties of tissues and providing a new dimension for the diagnosis of cancer hardness

Knowledge Corner: The Mystery of “Coherence” in OCT

Low-coherence interferometry (LCI) is the core technology of OCT. When the light beam reflected from the tissue meets the reference light beam, only the light with an optical path difference less than the coherence length of the light source will interfere. By measuring interference signals, OCT can precisely locate the depth position of scatterers - just like measuring the microscopic world of life with a “ruler” of light.



Full-field OCT (FF-OCT) : Breaking through the traditional resolution limit and achieving cell-level dynamic imaging. In breast cancer surgery, the experimental system has been able to determine within 20 seconds whether there are residual cancer cells at the resection margin

Chip-level light source: Columbia University has developed a millimeter-level supercontinuum light source chip, replacing traditional bulky lasers and paving the way for handheld OCT devices

Multimodal fusion: Combining OCT with photoacoustic imaging, fluorescence microscopy and other technologies to simultaneously obtain the triple information of structure, function and molecule. For example, in brain science research, such systems can observe hemodynamics and neuronal activities in parallel



Despite the bright prospects, OCT still faces practical constraints:

Penetration depth limitation: The strong scattering characteristics of light in biological tissues limit the effective detection depth to 2-3mm (skin) to 2-3cm (eye).

Data Ocean Challenge: A single OCT scan of the entire body skin generates data at the GB level, and more intelligent compression analysis algorithms need to be developed

Standardization dilemma: The differences in equipment parameters among different manufacturers lead to a decline in data comparability, and it is urgent to establish a cross-platform quality control system

While the latest published papers are still exploring how to optimize the OCT artificial intelligence model, innovators on the clinical front line have begun to rewrite patients' destinies with this technology. From subtle retinal lesions to fatal plaques in coronary arteries, from cancer cells beneath the skin to subtle swells of nerve fibers - this faint light of OCT, which piercings through the fog of life, is quietly reshaping the cognitive boundaries of modern medicine.

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Micro semi-automatic POCT products is transforming the landscape of diagnostic testing. Traditional luminescent reagents often rely on cold-chain transport, limiting their international reach. However, Poclight's innovative lyophilized spherical reagents can be stored at room temperature (2-30°C) with a shelf life of over 18 months, completely eliminating cold-chain requirements. This advancement not only enhances accessibility but also maintains the high precision levels expected from chemiluminescent assays.

Poclight's mini semi-automatic POCT device is designed for efficiency, with dimensions comparable to an A4 sheet and a weight of just 6 kg. This compact design ensures that healthcare providers can easily integrate the device into various clinical settings. With a testing speed of 120T/h and support for multi-project mixed sampling, it caters to diverse diagnostic needs without compromising performance.

One of the key features of Poclight's product is its use of homogeneous chemiluminescence technology, which guarantees high sensitivity and specificity for accurate testing. This precision is crucial for effective diagnosis and treatment, enabling healthcare professionals to deliver quality care to patients.

Additionally, single-use lyophilized reagents further simplify the testing process. The "foolproof" operation allows users to complete tests with just one sample addition, streamlining workflows and minimizing errors. This ease of use makes it particularly suitable for grassroots medical institutions, where resources may be limited.

Speed is another significant advantage, with results available in as little as 3 minutes. This rapid turnaround time empowers healthcare providers to make informed decisions quickly, ultimately improving patient outcomes. Moreover, Poclight's device offers a cost-effective solution, making it accessible for a wider range of healthcare facilities.

Micro Dry Honogeneous Chemiluminescence Immunoassay Analyzer and innovative lyophilized reagents represent a significant leap forward in diagnostic testing. With their compact design, rapid results, and simplified operation, they are well-positioned to meet the evolving needs of modern healthcare, paving the way for better patient care and broader accessibility.

As the demand for efficient and reliable point-of-care testing (POCT) solutions grows, mini semi-automatic POCT devices are emerging as game-changers in the industry. With dimensions comparable to an A4 sheet and weighing only 6 kg, Poclight's compact instruments are designed to meet the needs of healthcare providers looking for portability without sacrificing performance. Their ability to support multiple project mixed sampling makes them ideal for a variety of clinical settings.

One of the standout features of Poclight's mini semi-automatic POCT device is its use of homogeneous chemiluminescence technology. This method ensures high sensitivity and specificity, allowing for precise detection of biomarkers critical in patient diagnostics. By integrating this advanced technology, we provide healthcare professionals with the tools they need for accurate and timely results.

Additionally, Poclight's single-use CLIA lyophilized reagents can be stored and transported at room temperature, boasting a shelf life of up to 18 months. This significant advantage eliminates the constraints of cold-chain logistics, making it easier for manufacturers to expand into international markets. With Poclight's solution, laboratories can operate more flexibly, reducing overhead costs and improving accessibility.

Speed is another key benefit of Poclight's device. Reports can be generated in as little as 3 minutes, enabling healthcare providers to make quick decisions and improve patient outcomes. In an environment where time is of the essence, this rapid reporting capability is invaluable.

Moreover, Poclight's mini semi-automatic POCT device offers a higher cost-performance ratio. With lower testing costs, healthcare facilities can maximize their resources while providing quality care. The simplified equipment and user-friendly operation ensure that even grassroots medical institutions can easily integrate this technology into their workflows.

Poclight's mini semi-automatic POCT device represents a significant advancement in diagnostic testing. Its compact size, fast reporting, and innovative features position it as a competitive solution in the evolving healthcare landscape, paving the way for improved patient care and broader accessibility.

1.Thickening of subcutaneous fat

• Deeper vein location: The subcutaneous fat layer of obese people is thicker, which may cause the veins to be covered by fat, making them deeper and difficult to accurately locate through visual observation or touch (palpation).
  
• Blurred touch: Adipose tissue weakens the elastic touch of veins finder, making it difficult for medical staff to determine the location and direction of veins through touch.
  
  2. Venous physiological changes
  
• Venous compression or concealment: Obesity may cause veins to be compressed or encapsulated by surrounding adipose tissue, further concealing their location.
  
• Circulatory problems: Obesity is often accompanied by diseases such as hypertension and diabetes, which may cause venous hardening, reduced elasticity or vasoconstriction, increasing the difficulty of puncture.
  
  3. Clinical operation challenges
  
• Reduced success rate: Research shows that the initial success rate of venipaspiration in obese patients is relatively low, and multiple attempts may be required.
  
• Enhanced reliance on technology: Medical staff may need to rely on tools (such as ultrasound-guided) or longer needles, or choose special puncture sites (such as the back of the hand or the veins in front of the elbow).
  
  4. Other influencing factors
  
• Skin condition: Obese individuals may develop skin wrinkles or edema, which further mask the veins.
  
• Patient position: Some positions (such as hanging arms) may help fill the veins, but obese individuals may have difficulty cooperating due to limited movement.
  
  Coping strategy
  
• Ultrasound-guided: Real-time ultrasound imaging can precisely locate deep veins.
  
• Hot compress or making a fist: Promote blood vessel dilation and increase venous visibility.
  
  Experienced operators: Skilled medical staff can increase the success rate through anatomical landmarks and experience.
  
  Summary
  

  Obesity does increase the difficulty of venipesis, but it can be effectively dealt with through technical means and clinical experience. This conclusion is clearly supported in both medical literature and clinical practice (such as the Journal of Emergency Medicine and Nursing Research).

  
  

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Common causes: tractional retinal detachment (TRD) is mainly caused by the traction of the fibrous vascular membrane on the surface of the retina or within the vitreous. Adult TRD is most commonly seen in proliferative diabetic retinopathy (PDR), retinal vein occlusion (RVO), retinal vasculitis and proliferative vitreoretinopathy (PVR). In addition, trauma, sickle cell retinopathy and uveitis, etc. can also lead to TRD. TRD in children is commonly seen in congenital diseases such as familial exudative vitreoretinopathy (FEVR), retinopathy of prematurity (ROP), and persistent primary vitreous hyperplasia (PHPV).

Clinical manifestations: The patient's symptoms are closely related to the location and extent of the traction. Typical manifestations include: Decreased vision: Posterior pole detachment can cause a sharp decline in central vision, while early peripheral detachment may be asymptomatic. Visual field defect: Fixed direction black shadow occlusion, a certain area of the visual field: "curtain" -like occlusion. Floaters and flashes of light: When the eyes move, brief "lightning-like" or "fire-like" flashes appear before the eyes, mostly around the visual field. Sudden drop in central vision + distorted vision: This highly indicates macular involvement. If not treated promptly, it may cause irreversible vision damage, such as scar formation and photoreceptor cell necrosis.

Diagnostic method: Fundus examination: After mydriasis dilation, the indirect ophthalmoscope can reveal the fibrous vascular membrane and its traction on the retina, with or without vitreous hemorrhage. Optical coherence tomography (OCT) : High-resolution display of the morphology of each layer of the retina, assessment of the position of the traction membrane and the involvement of the macular area. B-ultrasound: It is suitable for patients with severe vitreous opacity to assess the degree of traction and the extent of detachment. Fluorescein fundus angiography: It helps identify neovascularization, non-perfusion areas and lesion distribution, which is beneficial for surgical planning.

Treatment and prognosis: Vitrectomy (PPV) : Removing the proliferative membrane and releasing traction, combined with gas or silicone oil filling to reposition the retina, is the preferred surgical method for TRD. Laser photocoagulation: Targeting ischemic areas or around holes, it reduces new blood vessels and leakage. Anti-vegf drugs: Preoperative injection can reduce the vascular activity of the proliferative membrane and lower the risk of intraoperative bleeding. External scleral compression surgery: It is suitable for peripheral detachment and reduces vitreous traction through external pressure. Postoperative management: Regular follow-up is necessary. Avoid strenuous exercise and intraocular pressure fluctuations. Supplement neurotrophic drugs (such as vitamin B1 and adenosine triphosphate) to promote functional recovery.

Preventive strategies: Control underlying diseases: For instance, patients with diabetes and hypertension need to strictly manage their blood sugar and blood pressure to delay the progression of retinopathy. Regular ophthalmic screening: High-risk groups (patients with high myopia and diabetes) should have fundus examinations every year. Avoid ocular trauma: Especially for those engaged in high-risk occupations, protective equipment should be worn. Timely treatment of vitreous hemorrhage: Early intervention can reduce the formation of organized membranes.

The symptoms of tractional retinal detachment are centered around painless visual abnormalities. In the early stage, they may only present as mild floaters or flashes, which are easily overlooked. As the traction intensifies, visual field defects, distorted vision and decreased vision gradually occur. Due to the significant individual differences in symptoms, especially among high-risk groups such as diabetes and high myopia, even if there are no obvious discomforts, regular fundus screening (such as OCT and fundus fluorescein angiography) is still necessary to avoid delaying treatment due to "asymptomatic" conditions. Once the above warning signals occur, it is essential to visit an ophthalmologist as soon as possible and undergo surgery (such as vitrectomy) to relieve the traction and reposition the retina, so as to save vision to the greatest extent.

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1.The application of Doppler ultrasound technology in venous localization

A research team from the Georgia Institute of Technology in the United States has developed a low-cost handheld device that uses Doppler ultrasound technology to quickly locate veins. This device distinguishes arteries from veins by emitting ultrasonic beams and analyzing blood flow reflection signals, and guides punctures in real time. It is particularly suitable for situations where veins are difficult to locate, such as in patients with trauma or burns. This technology has entered the human testing stage and is expected to achieve a portable design the size of a pen in the future.



2. Market and Technological Trends of Projection Vein Detectors

Technical classification: Laser, infrared and ultrasonic are the mainstream technologies. Laser technology has high precision and is suitable for intravenous injection and sclerotherapy. Infrared technology is low in cost and portable, and is often used for first aid. Ultrasound is widely used in vascular surgery due to its non-invasiveness and deep vein imaging ability.

Market-driven: The rising incidence of vascular diseases (such as varicose veins and deep vein thrombosis) and the increasing demand for minimally invasive surgeries have driven market development. By 2032, the global market size is expected to reach 10.8 billion US dollars, with a compound annual growth rate of 9.05%.



3. Technological breakthroughs in Infrared vein detectors and their impact on the supply chain

Technological progress: Near-infrared (NIR) imaging technology has significantly enhanced the accuracy of vein visualization, especially suitable for obese or dark-skinned patients. The portability of handheld devices makes them applicable in home care and remote areas.

Trade policy impact: The additional tariffs imposed by the United States have affected the technological flow and supply chain layout of the infrared vein detector industry, prompting Chinese enterprises to accelerate localized research and development, and at the same time promoting international enterprises to adjust their global value chains.



4. Vein recognition and biometric technology

The BK series of dorsal hand vein recognition systems developed by NEXTERN of South Korea and the palm vein imaging technology of Fujitsu of Japan both capture the distribution of subcutaneous veins through infrared rays and are applied in the field of identity authentication. Research from the University of Tennessee in the United States utilized CCD cameras combined with infrared filters to capture vein images, exploring their potential in the medical and security fields.



5. Tip catheter positioning technology (such as the Sherlock 3CG system)

The Sherlock 3CG system recommended by the American Society of Intravenous Infusion Nurses (INS) combines magnetic tracking and ultrasound guidance to achieve real-time positioning of PICC catheter insertion. This technology precisely determines the position of the catheter tip through changes in electrocardiogram signals (such as color changes in P-waves), reducing X-ray exposure and the risk of complications. It has been clinically promoted abroad.



6. Non-invasive central venous pressure (CVP) measurement technology

A research team from Massachusetts General Hospital in the United States has developed quantitative compression ultrasound (QCU) technology to non-invastively estimate CVP by measuring the collapse force of the internal jugular vein. Studies have shown that the accuracy of QCU is significantly higher than that of the traditional jugular pulse height measurement method, providing a new tool for the monitoring of diseases such as heart failure.



7. Clinical Application and Market Pattern of Venous Viewing Devices

The main enterprises: AccuVein (handheld infrared device), VeinViewer (high-precision projection technology), BD (medical equipment giant), etc. dominate the market. AccuVein’s products have become industry benchmarks due to their portability and real-time imaging capabilities.

Application scenarios: Hospitals (blood drawing, intravenous injection), clinics (minimally invasive surgery), and blood donation centers (efficient blood collection) are the main application fields, with North America and Europe occupying the largest market share.



8. Neuroscience correlation research of venous imaging

The study published in "Nature Communications" utilized the displacematic MRI (DiSpect) technique to reveal the hemodynamic changes of the cerebral venous system during neural activation. This technology not only enhances the resolution of venous imaging, but also provides a new perspective for the diagnosis of brain diseases such as stroke and multiple sclerosis.

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The new technology for finding veins usually refers to one of the biometric technologies, namely vein recognition technology. Vein recognition is a biometric technology that verifies an individual’s identity by scanning and analyzing the vein images of a person’s fingers or hands. It uses the biological characteristics of the human venous system for identity authentication. These biological characteristics are unique to each person and difficult to forge, thus having high security and accuracy.



Regarding new technologies for finding veins, there are continuous new researches and developments to enhance recognition accuracy, precision and speed, while reducing costs and improving user experience. Some new technologies and trends include:



1.Multimodal biometric recognition: Combining vein recognition with other biometric features, such as fingerprint and facial recognition, to enhance recognition accuracy.



2.3D venous imaging: Utilizing three-dimensional imaging technology to obtain more detailed venous structure information, enhancing security and resisting attacks from biometric photos or models.



3. Mobile devices: Introduce miniaturized and portable vein recognition devices to provide more flexible solutions for mobile devices and machines.



4. Blockchain Technology: By integrating blockchain technology, ensure the secure storage and sharing of vein data, and protect user privacy and identity security.



5. Cloud Integration: Integrate vein recognition technology with cloud computing and the Internet of Things to provide more convenient identity verification solutions, such as applications in healthcare, finance, logistics and other fields.

The development of these new technologies has led to significant progress in vein recognition technology in terms of security, reliability and user experience, providing a wider range of applications for various fields.

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